Pharmacological Inhibition of Host Heme Oxygenase-1 Suppresses Mycobacterium tuberculosis Infection In Vivo by a Mechanism Dependent on T Lymphocytes.

In parallel experiments in which animals were euthanized at 2 weeks after treatment initiation, SnPPIX-treated infected TCR-α −/− mice displayed bacterial loads indistinguishable from those in untreated TCR-α −/− animals, while WT animals treated with the compound showed a highly significant reduction in mycobacterial burden compared to untreated control mice ( Fig. 1E ).

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