Dose and Fractionation in Radiation Therapy of Curative Intent for Non-Small Cell Lung Cancer: Meta-Analysis of Randomized Trials.

When these comparisons were grouped according to whether the protocol specified no chemotherapy, sequential chemotherapy, or concurrent chemotherapy the heterogeneity between these groups was highly significant ( P =.001).

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So, surprisingly, the median survival ratio increased progressively with increasing EQD2T in the lower-dose arm, with an increasing trend across the 3 groups ( P for trend=.01).

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