IL-33 delivery induces serous cavity macrophage proliferation independent of interleukin-4 receptor alpha.

In contrast, there was a highly significant reduction in RELMα expression within peritoneal macrophages (Fig. 3 C and D) and secreted RELMα and Ym1 protein (Fig. 3 E) within the peritoneal lavage fluid of the IL‐4Rα deficient animals, confirming a requirement for IL‐4Rα signaling for induction of these alternative activation markers.

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