No Reliable Association between Runs of Homozygosity and Schizophrenia in a Well-Powered Replication Study.

Across all thresholds, the only thresholds that approached significant associations between Froh and schizophrenia in the replication data were at the upper limits of the Mb-length ROH thresholds; the strongest association was for ROHs defined as ≥ 19 Mb (β = 8.64, CI(β) = [−0.85,18.13], Z = 1.78, p = 0.07).

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Discussion Despite exploring various homozygous SNP length thresholds, Mb thresholds, and combinations of covariates, the findings from this study do not lend much support to the original observation of a highly significant Froh -schizophrenia association[ 20 ], and provide only equivocal support, based on combining the original and replication data, for the hypothesis that autozygosity is a risk factor for schizophrenia.

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