Both OCIP23 and OCIP51 tumors treated with either TH-302 or IR showed a highly significant increase in tumor necrosis when compared to the control, that was not observed in OCIP19 and OCIP110 ( Supplementary Figure 4C ).
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Targeting hypoxic microenvironment of pancreatic xenografts with the hypoxia-activated prodrug TH-302.
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