A role for multiple chimeric antigen receptor-expressing leukocytes in antigen-specific responses to cancer.

However, while similar levels of cytotoxicity were observed from both WT and CAR NK cells against the parental RMA cell line (Figure 3D , NS at all E:T ratios), a comparison of WT and CAR NK cells co-cultured against RMAERB targets showed highly significant antigen specific cytotoxicity, indicating the ability of CAR NK cells to recognise and perform cytotoxic function through the chimeric antigen receptor (Figure 3D ).

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