Systemic release of osteoprotegerin during oxaliplatin-containing induction chemotherapy and favorable systemic outcome of sequential radiotherapy in rectal cancer.

In multivariate analysis, entering baseline variables with significant association with PFS, low hemoglobin remained associated with adverse PFS while OPG (HR 2.55; P = 0.051) failed to reach significance ( Supplementary Table 1 ).

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On the one hand, high baseline serum OPG levels were associated with unfavorable PFS, though it just failed to reach significance in multivariate analysis.

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