Validating genetic markers of response to recombinant human growth hormone in children with growth hormone deficiency and Turner syndrome: the PREDICT validation study.

Large candidate gene analyses have evolved into genome-wide association studies (GWAS) over the last 10 years, which have demonstrated success at detecting highly significant effects of common gene variants ( 22 ), but which have generally failed to explain more than a small amount of the phenotypic variability within datasets ( 23 ).

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