Temporal trends in the risk of developing multiple primary cancers: a systematic review.

BMC Cancer · 2016 · PMC5097442 · PMID 27814758

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an increasing trendno p-value reported

Four of them observed an increasing trend in MPC risk from earlier to more recent periods.

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a decreasing trendno p-value reported

Six studies reported an increasing temporal trend in MPC risk [ 32 , 34 , 42 , 53 , 54 , 56 ], whilst two studies reported a decreasing trend in MPC risk after breast cancer during the study period 1943–2000 [ 31 , 37 ].

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