Quinolinic acid injection in mouse medial prefrontal cortex affects reversal learning abilities, cortical connectivity and hippocampal synaptic plasticity.

Sci Rep · 2016 · PMC5098239 · PMID 27819338

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However after surgery, RM-ANOVA revealed a highly significant main effect of treatment group on path length during reversal trials (F 1,21 = 8.7, p = 0.007), which demonstrated that MWM reversal was markedly impaired in mice with mPFC lesions.

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