CD20 monoclonal antibody targeted nanoscale drug delivery system for doxorubicin chemotherapy: an in vitro study of cell lysis of CD20-positive Raji cells.

This pH-sensitive release of DOX may be significant because of the acidic microenvironments found in tumor tissues and cell lysosomes. 36 The DL content of DOX in the NDDS, ACNP-DOX-DSPE-PEG2000-anti-CD20 was 20.1%±1.6%, which was less than that for the ACNP-DOX-DSPE-PEG2000 complex (29.8%±2.56%) and the ACNP-DOX complex (31.2%±2.64%), as shown in Table 1 , which may be attributed to the increasing size of the complex, including the additional conjugated antibody.

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