Management of rheumatoid arthritis during pregnancy: challenges and solutions.

62 Utilizing the European Network of Teratology Information Services, major birth defects were reported in 5% of exposed as compared to 1.5% in nondiseased controls with borderline significant risk. 63 In terms of fetal abnormalities in another cohort of individuals exposed to infliximab, one patient had Tetralogy of Fallot, one child had intestinal malrotation, and one twin had delayed development and hypothyroidism. 64 In the TREAT registry for Crohn’s disease, there were 142 pregnancies with exposure to infliximab with healthy babies in 92.4% compared to 85.3% receiving other treatments. 65 In the OTIS RA Pregnancy Project, a total of 32 patients were compared to women with RA but not on anti-TNF and women without RA.

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