Metformin Ameliorates Dysfunctional Traits of Glibenclamide- and Glucose-Induced Insulin Secretion by Suppression of Imposed Overactivity of the Islet Nitric Oxide Synthase-NO System.

Notably, it should be recalled that we have shown previously that N G -nitro-L-arginine methylester (L-NAME) a selective ncNOS inhibitor in isolated murine islets [ 17 , 27 ] brought about a highly significant increase in glibenclamide-induced insulin release both in vitro and in vivo [ 28 ].

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