Barely Significant
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Novel m4C modification in type I restriction-modification systems.

Nucleic Acids Res · 2016 · PMC5100572 · PMID 27580720

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highly significantno p-value reported
Alignment of the S subunit protein sequences revealed highly significant similarity in the N-terminal TRDs (TRD1), but little sequence similarity in the C-terminal TRDs (TRD2), suggesting that TRD1 was responsible for CCC recognition and TRD2 was responsible for the m6A-modified half-site recognition.

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