Efficacy, tolerability, and safety of an oral enzyme combination vs diclofenac in osteoarthritis of the knee: results of an individual patient-level pooled reanalysis of data from six randomized controlled trials.

J Pain Res · 2016 · PMC5104298 · PMID 27853388

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highly significantno p-value reported

DIC but not OEC treatment was associated in the majority of patients with noticeable and statistically highly significant increases of the key liver enzymes AST, ALT, and GGT at study end vs baseline.

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