Role of RNA secondary structure in emergence of compartment specific hepatitis B virus immune escape variants.

World J Virol · 2016 · PMC5105049 · PMID 27878103

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highly significantno p-value reported

Nevertheless, the finding of selective predominance of the point mutation leading to G145R in the present study is highly significant in the context of PBL, since PBLs are exposed to strong anti-HBs humoral immune response and HBV variants with G145R are capable of strongly neutralizing this immune response, without any compromise in the replicative competence, thereby ensuring viral perseverance[ 29 , 30 ].

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