Soluble pre-fibrillar tau and β-amyloid species emerge in early human Alzheimer's disease and track disease progression and cognitive decline.

In Western blots, a single immunoreactive band was identified migrating ~12 kDa, which in a subset of samples approached significant elevations based on diagnosis and when samples grouped in low, intermediate and high Braak stages ( p = 0.07 and p = 0.08, respectively), but did correlate with individual Braak stages ( r = 0.32, p < 0.05; data not shown).

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4 a ii, p < 0.05) but failed to reach significance across grouped Braak stages (Fig. 4 a iii, p = 0.09).

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