Breast cancer risk prediction using a polygenic risk score in the familial setting: a prospective study from the Breast Cancer Family Registry and kConFab.

There were highly significant differences between the mean PRS in affected women at baseline compared to unaffected women in each cohort as well as the combined set (p=3x10 −5 , 1x10 −6 , and1x10 −10 , respectively).

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The HRs for the continuous PRS were not significantly different between the BCFR and kConFab study cohorts (p=0.13) for study*PRS interaction, but were borderline significant for the upper vs. lower quintile (P=0.05), nor did the HR vary significantly as a function of age at baseline (p=0.88 and p=0.71 for the two cohorts, respectively).

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