Determining the Molecular Pathways Underlying the Protective Effect of Non-Steroidal Anti-Inflammatory Drugs for Alzheimer's Disease: A Bioinformatics Approach.

Again, the Ribosome pathway was the most highly significant, with a p-value that would survive multiple comparisons correction (p = 7.38 × 10 -7 , see Supplementary Table 2 and Fig. 2 B).

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However, in contrast to blood, we found no pathway simultaneously dysregulated in both cell lines exposed to NSAIDs and post-mortem AD brain at our pre-specified level of significance (p < 1 × 10 – 4 ), although all three pathways, identified as dysregulated in AD brain come close to significance.

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