Diversification in the HIV-1 Envelope Hyper-variable Domains V2, V4, and V5 and Higher Probability of Transmitted/Founder Envelope Glycosylation Favor the Development of Heterologous Neutralization Breadth.

PLoS Pathog · 2016 · PMC5112890 · PMID 27851829

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highly significantno p-value reported

That is, a non-conservative amino acid change that just meets the significance threshold (-3) will have 3 points, but is not weighted equally to the same change with a highly significant Z-score of -30, which will result in 30 points.

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