Postarrest stalling rather than crawling favors CD8(+) over CD4(+) T-cell migration across the blood-brain barrier under flow in vitro.

We found that absence of endothelial ICAM‐1 led to a slight but not quite significant reduction of the shear‐resistant arrest of CD8 + T cells on TNF‐α+IFN‐γ‐stimulated pMBMECs when compared to wild‐type (WT) pMBMECs from 45 ± 19 to 37 ± 12 cells per FOV and on TNF‐α‐stimulated pMBMECs from 33 ± 16 to 23 ± 6 cells per FOV (Supporting Information 4).

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