Tumor immune microenvironment characterization in clear cell renal cell carcinoma identifies prognostic and immunotherapeutically relevant messenger RNA signatures.

However, the ssGSEA-based TIS had at least borderline significant correlation with both of these variables despite the small number of samples ( p = 0.047 for the correlation with IHC-based T cell counts and 0.057 for the correlation with total TCRb read counts) (Fig. 7b , middle and right panels).

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Out of 13 tumor types, 10 exhibited Spearman correlations greater than 0.6 and all 13 had highly significant p values (Fig. 2b , Additional file 1 : Figure S6 left column).

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