Yet, both interface areas are larger than 856 Å 2 , an empirical cut-off that can distinguish biological interfaces from crystal contacts with 85% accuracy ( Ponstingl et al., 2000 ), and our analysis of the Pcdh19-I2 interface lacks contributions from possible EC1-EC5 contacts, which might be significant.
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Structural determinants of adhesion by Protocadherin-19 and implications for its role in epilepsy.
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