Axl-EGFR receptor tyrosine kinase hetero-interaction provides EGFR with access to pro-invasive signalling in cancer cells.

10 Axl signalling was also shown to be able to drive migration and extravasation of breast cancer cells from the bloodstream even in the absence of vimentin, indicating that Axl is a highly significant regulator of metastasis. 10 This is further supported by the fact that Axl has been shown to regulate migration/invasion through induction of matrix metalloproteinase 9 (MMP9). 11 In addition, Axl activation stimulated by its ligand Gas6 induced expression of the pro-survival family of proteins Bcl

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