The Impact of Diabetes Mellitus on Vascular Biomarkers in Patients with End-Stage Renal Disease.

17 In echocardiography examinations, however, the association between DM and E/E’ showed marginal significance in multi-variate analysis, and DM patients seemed to have higher E/E’, which represents increased LV filling pressure. 8 This result suggests that: 1) DM ESRD patients might be prone to pulmonary congestion and/or heart failure symptoms during cardiac volume/pressure overload despite normal LV EF; and thus, 2) more aggressive LV unloading by renal replacement therapy and/or anti-heart failure medications should be considered in the setting of ESRD and DM.

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