The effect size for an indicator variable showing whether a CRR was chosen or rejected was 0.46+/−0.02 ( p < 2 × 10 −16 ,Wald test), revealing a highly significant effect on the (log) expected mutation counts consistent in size with observed differences in average mutation counts from Table 2 .
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Cancer somatic mutations cluster in a subset of regulatory sites predicted from the ENCODE data.
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