borderline significanceP = 0.041
We thus adopted a linear model for pack year and observed borderline significance for an increased risk of early AMD features by pack year in men, but not in women (P overall = 0.059, men: OR = 1.007 per pack year, P = 0.041; women: OR = 0.989, P = 0.201, model with interaction of pack year with sex and sex-specific spline for age, Table 3 ).