Predictors of long-term response to abiraterone in patients with metastastic castration-resistant prostate cancer: a retrospective cohort study.

At the univariate analysis, a significant correlation with the duration of abiraterone exposure was found for Gleason score (HR 0.82, 95% CI 0.71-0.96; p=0.012), PSA (HR 1.10, 95% CI 1.03-1.18; p=0.08) and lactic dehydrogenase levels (HR 1.22, 95% CI 1.02-1.46; p=0.027), while the association between lower alkaline phosphatase levels and treatment duration was marginally significant (HR 1.07, 95% CI 0.99-1.16; p=0.074).

also in 26,082 other papers

The association between ALP and abiraterone exposure did not quite reach statistical significance (HR 1.07, 95% CI 0.99-1.16; p =0.074; unit=100 U/L).

also in 679 other papers

In conclusion, our retrospective analysis in patient with mCRPC, mostly treated in post-docetaxel setting, showed that high Gleason score, lower PSA and LDH levels before starting abiraterone were significantly associated with long-term abiraterone exposure (a marginal significance being found for lower ALP).

also in 5,069 other papers