The role of IL-10 in Mycobacterium avium subsp. paratuberculosis infection.

Cell Commun Signal · 2016 · PMC5131435 · PMID 27905994

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IL-10 overexpressed transgenic mice challenged with Mtb via respiratory route shown a highly significant increase in bacterial number in the lungs, while decreased mRNA production of TNF-α and IL-12p40, and a marked decrease in the secretion of Ag-specific IFN-γ was observed [ 72 ].

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