Consistent sex-dependent effects of PKMζ gene ablation and pharmacological inhibition on the maintenance of referred pain.

However, at six weeks, when allodynia has developed in the hind paw contralateral to the nerve injury ( Figure 1(e) ), ZIP produced transient, but highly significant increases in contralateral PWTs at 30 min ( F 1,10 = 10.627, p = 0.009) and 60 min ( F 1,10 = 12.438, p = 0.005), without effects on ipsilateral PWTs ( Figure 1(f) ).

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