highly significantP < 0.0001
The differing tissue-specific temporal expression profiles of Sgk1 mRNA between the PFC and the pituitary were confirmed by two-way ANOVA with highly significant effects of time ( F (10,83) = 17.46, P < 0.0001), tissue ( F (1,83) = 42.82, P < 0.0001), and interaction ( F (10,83) = 3.10, P < 0.01).