Prediction of Impending Type 1 Diabetes through Automated Dual-Label Measurement of Proinsulin:C-Peptide Ratio.

However, normalizing PI:C for HOMA2-IR unveiled a highly significant hyperbolic correlation (r s = -0.596; P <0.001) with AUC 5-10min C-peptide, andalso with AUC 120-150min C-peptide, only available for age 12–39 years (n = 31; r s = -0.529; P = 0.002) ( Fig 2C ).

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