Transitional B Cells in Early Human B Cell Development - Time to Revisit the Paradigm?

It was interesting that in the BM this was particularly the case, with IGHV3 cells actually being removed from the repertoire during B cell maturation: there is a highly significant >13% decrease in the use of IGHV3 family genes in naïve cells with small increases in all other families to compensate (Figure 2 A).

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