Transglutaminase 2 is dispensable but required for the survival of mice in dextran sulfate sodium-induced colitis.

14 Intriguingly, pathway analyses of these genes revealed a highly significant association between IBD and the IL-23 signaling pathway (IL23R, TYK2, JAK2, STAT3 and CCR6) as well as the NF-κB signaling pathway (REL, TNFAIP3 and NFKB1), emphasizing that Th17 cell differentiation is importantly implicated in triggering the intestinal inflammation of IBD. 15 , 16 , 17 Moreover, significantly high levels of TG2 autoantibody have been detected in the serum of Crohn's disease and ulcerative colitis patients, 18 indicating that TG2 might be activated in the inflamed intestine of IBD.

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