Integrative epigenome-wide analysis demonstrates that DNA methylation may mediate genetic risk in inflammatory bowel disease.

Nat Commun · 2016 · PMC5133631 · PMID 27886173

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highly significantno p-value reported

In our own study in treatment-naive children with CD, highly significant differences in DNA methylation were noted to occur in genes implicated in disease pathogenesis 16 .

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Quoted from the open-access full text in Europe PMC under the licence the publisher applied. The sentence is reproduced exactly as published; the emphasis is ours.