Combined genotype and haplotype distributions of MTHFR C677T and A1298C polymorphisms: A cross-sectional descriptive study of 13,473 Chinese adult women.

On the contrary, the 1298C allele frequency showed a decreasing trend from Hainan province (25.7%) to Shandong province (13.1%) (Table 2 ). 3.2 Haplotypes The LD analysis showed that the D’ and r 2 values were 0.883 and 0.143, respectively, in the total sample, which indicates that the MTHFR C677T and A1298C polymorphisms were at high LD.

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