Codon usage is less optimized in eukaryotic gene segments encoding intrinsically disordered regions than in those encoding structural domains.

Nucleic Acids Res · 2016 · PMC5137448 · PMID 27915289

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a decreasing trendno p-value reported

In most cases, the ratio shows a decreasing trend with distance from the nearest SD/IDR boundary. tAI analyses with corrections for amino acid composition However, the mean tAI in IDRs cannot simply be compared with that in contiguous SDs as amino acid compositions of IDRs and SDs differ.

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