highly significantp < 0.001
In both sexes, highly significant correlations were found between A S and the number of S copies in the genotype (Pearson’s correlation coefficient: r = 0.82, t = 16, df = 117, p < 0.001 and r = 0.84, t = 15, df = 96, p < 0.001, for females and males, respectively), and between A R and the number of R copies in the genotype ( r = 0.96, t = 37, df = 117, p < 0.001 and r = 0.93, t = 26, df = 96, p < 0.001, for females and males, respectively; S2 Fig ).