Systemic TLR2 agonist exposure regulates hematopoietic stem cells via cell-autonomous and cell-non-autonomous mechanisms.

We observed a nonsignificant trend toward increased HSC frequency only in cases where hematopoietic cells expressed TLR2 (WT→WT and WT→ Tlr2 −/− ; Figure 4a ); however, spleen HSPCs increased in all three chimeric groups ( Figures 4b and c ), suggesting that TLR2 expression on either radioresistant (that is, mostly stromal) or radiosensitive (hematopoietic) cells is sufficient to induce some mobilization (or expansion) of spleen HSPCs.

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