Skeletal muscle characteristics are preserved in hTERT/cdk4 human myogenic cell lines.

As these can be considered borderline significant, we include a heatmap (Additional file 1 : Figure S1) showing the expression levels of genes that are driving this effect (defined by the overlap of GSEA leading edges).

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For instance, it is informative to contrast those results with the following: when genes of our dataset were ranked according to their change in myotubes v myoblasts, GSEA on the muscle gene sets specifically identified strong overlap with 35 of the 393 muscle gene sets with a very highly stringent statistical cut-off of FDR < 0.001: these highly significant muscle gene sets are visualized using an enrichment map—this shows gene sets that were downregulated (in myotubes v myoblasts) in blue with color intensity proportional to the enrichment score (none of these highly significant gene sets were upregulated in this case), and grey connections represent the sharing of genes between gene sets (i.e., some gene sets are similar to each other) (Additional file 1 : Figure S2).

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