SCN4B acts as a metastasis-suppressor gene preventing hyperactivation of cell migration in breast cancer.

Lower levels of the SCN4B gene transcript in breast cancer tissues, compared with non-cancer tissues, were also found to be highly significant in RNA sequence expression analysed from The Cancer Genome Atlas Network ( Fig. 2e ) and to be associated with an increased risk of metastatic relapse or death in breast cancer patients ( Fig. 2f,g ).

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