BLR1 and FCGR1A transcripts in peripheral blood associate with the extent of intrathoracic tuberculosis in children and predict treatment outcome.

Out of the 11 tested transcripts, only BLR1 and FCGR1A had a significant association ( Table 2 ): At baseline, every log unit increase in baseline BLR1- levels decreased the likelihood for an unfavourable outcome at 2 months by 30% (OR BLR1 0.70, 95%CI[0.50;0.98]), but at the same time, an increase in BLR1- levels from baseline to 2 months increased the likelihood for an unfavourable outcome with borderline significance (OR BLR1 1.77, 95%CI[1.00;3.13]), which likely reflects a steeper increase in BLR1 levels on treatment in children with low levels at baseline - possibly indicative of severe disease.

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