Impact and Effectiveness of 10 and 13-Valent Pneumococcal Conjugate Vaccines on Hospitalization and Mortality in Children Aged Less than 5 Years in Latin American Countries: A Systematic Review.

PLoS One · 2016 · PMC5152835 · PMID 27941979

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a decreasing trendno p-value reported

Both interrupted time series studies conducted in Chile [ 45 ] and Brazil [ 32 ] showed a decreasing trend after PCV introduction in children aged <2 years contrasting with non-decreasing trend in rates in age groups not targeted by PCV.

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