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An evaluation of early medication use for COPD: a population-based cohort study.

Int J Chron Obstruct Pulmon Dis · 2016 · PMC5153270 · PMID 27994449

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an increasing trendno p-value reported
This pattern of multiple inhaler use with an increasing trend over time is not dissimilar to our findings, which analyzed first-time medication prescriptions specifically.

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Quoted from the open-access full text in Europe PMC under the licence the publisher applied. The sentence is reproduced exactly as published; the emphasis is ours.