A previous study showed decreased osteocalcin concentration with increased age, but osteocalcin levels showed an increasing trend in postmenopausal women and men over the age of 70.[ 15 ] On multiple regression analysis, serum osteocalcin level showed negative correlation with fasting blood glucose and HOMA-IR after adjusting for age, sex, and menopausal status and this correlation was independent with ALP, calcium, and phosphorus concentration.
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Association of Serum Osteocalcin with Insulin Resistance and Coronary Atherosclerosis.
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