highly significantp < 10 −5
Analysis of the microarray data revealed that there was indeed a single, highly significant ( p < 10 −5 ) chromosomal cluster of genes negatively regulated by VHL-1 in a HIF-1–independent manner and that in total this cluster extended over 110 kb to include F56A4.9, Y45G12C.9, Y45G12C.12, and Y45G12C.2 in addition to the six genes validated by RNase protection assay.