Aldo-keto reductases are biomarkers of NRF2 activity and are co-ordinately overexpressed in non-small cell lung cancer.

Br J Cancer · 2016 · PMC5155360 · PMID 27824809

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highly significantno p-value reported

A comparison of samples wild type or mutant for the NRF2 pathway demonstrated a highly significant enrichment of mRNA for all four AKR genes in mutant cases, in both AC and SCC ( Figure 4 ).

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