Phosphatidylinositol 4-kinase IIβ negatively regulates invadopodia formation and suppresses an invasive cellular phenotype.

Although we are cautious in drawing conclusions, we are aware that this finding may be highly significant and therefore speculate that PI4KIIβ acts as a metastasis suppressor by maintaining PI(4)P-dependent post-TGN traffic into the endolysosomal pathway.

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