When the estimated mRNA folding energy was compared to protein accessibility, a highly significant positive correlation between Δ G min and ACC was observed for all organisms (Spearman correlation coefficient [SP] between 0.38 and 0.6 [hereinafter, when describing correlations, we use the Spearman correlation coefficient unless otherwise indicated]; P -value < 0.005) (Figure 1 and Supplementary Table S1), and a somewhat lower but also significant (with the exception of yeast) positive correlation was found for Δ G mean (between 0.15 and 0.54; P -value < 0.05), whereas only weak negative correlation was detected for Δ G max (Supplementary Table S1).
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