Omega-3 carboxylic acids monotherapy and combination with statins in the management of dyslipidemia.

34 A subgroup analysis published 2 years later found that in those with both the highest TG (>198 mg/dL) and lowest HDL-C (<33 mg/dL) tertiles, the addition of extended-release niacin to simvastatin provided a greater reduction in the primary end point with HR of 0.74, which almost reached statistical significance ( p =0.073). 35 If TG and HDL-C cut-off points were slightly adjusted to ≥200 and <32 mg/dL, respectively, a significant reduction in the primary end point was then observed with a HR of 0.64 ( p =0.032).

also in 378 other papers